Substance Name: Propylene Glycol BIO
Synonyms: 1,2-Propanediol, PG, Monopropylene Glycol
CAS Number: 57-55-6
Recommended Use: Solvent in pharmaceuticals, food additive, personal care, industrial coolant
Manufacturer: [Your Company’s Name]
Emergency Contact: Local Poison Control, Fire Department, (local contact number)
GHS Classification: Not classified as hazardous by OSHA or GHS
Signal Word: None
Hazard Statements: Not expected to pose acute health hazards; large ingestion may cause nausea
Pictograms: None required
Precautionary Statements: Avoid eye contact, do not ingest large quantities, maintain good industrial hygiene
PPE Recommendations: Standard work gloves, goggles in case of splashes
Chemical: Propylene Glycol BIO
Chemical Formula: C3H8O2
Content: >99.5% Propylene Glycol (Bio-based)
Impurities: Water (<0.5%), organics (trace amounts, proprietary, derived from biorenewable sources)
Additional Information: Meets standards set for USP, FCC, and food-grade applications
Inhalation: Move exposed person to fresh air, keep warm and calm, seek medical attention if symptoms persist
Skin Contact: Rinse skin with lukewarm water and soap, remove contaminated clothing, consult physician if irritation develops
Eye Contact: Flush eyes with flowing water for at least 15 minutes, keep eyelids open, seek medical guidance for persistent symptoms
Ingestion: Rinse mouth, drink water to dilute, do not induce vomiting, get medical advice if a large amount was ingested or symptoms develop
Most Important Symptoms: Mild irritation to eyes or skin, nausea following ingestion of large amounts
Suitable Extinguishing Agents: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Media: Direct water jet for large spills may spread the fire
Specific Hazards: Burning releases carbon oxides (CO, CO2), thermal decomposition can yield irritating fumes
Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Additional Advice: Evacuate downwind area, contain fire water run-off to prevent environmental contamination, cool nearby containers
Personal Precautions: Use gloves, goggles, avoid skin and eye contact
Environmental Precautions: Prevent runoff into drains, surface water, or soil
Spill Cleanup: Absorb with inert material like sand or earth, use non-sparking tools, place in suitable container for disposal
Ventilation: Ensure good airflow, especially in enclosed spaces
Disposal: Dispose of according to local regulations, avoid contamination of water sources
Safe Handling: Handle in accordance with industrial hygiene and safety practices, avoid unnecessary exposure, keep containers tightly closed
Compatibility: Keep away from strong oxidizers, acids, and bases
Storage Conditions: Cool, dry, and well-ventilated storage area, protect from moisture and direct sunlight
Storage Materials: Stainless steel, polyethylene, high-density polyethylene containers recommended
Special Rules: Ensure proper labeling, keep out of reach of children and unauthorized personnel
Occupational Exposure Limits: Not established for Propylene Glycol, follow general workplace guidelines
Engineering Controls: Use local exhaust ventilation for large-scale operations
Personal Protection: Safety goggles, chemical-resistant gloves, standard protective clothing
Respiratory Protection: Not required under normal use, NIOSH-approved mask for high aerosol concentrations
Hygiene Measures: Wash hands after handling, avoid eating or drinking in work area
Appearance: Clear, colorless, nearly odorless, viscous liquid
Boiling Point: 188.2°C
Melting Point: −59°C
Flash Point: 104°C (closed cup)
Vapor Density: 2.6 (air = 1)
Solubility: Completely miscible with water, alcohol, acetone
pH: Neutral (6.0–7.5)
Relative Density: 1.0361 g/cm³ at 20°C
Partition Coefficient (n-octanol/water): −0.92
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Low reactivity, not prone to hazardous polymerization
Hazardous Reactions: Reacts with strong oxidizing agents, may form explosive mixtures with air at high temperatures
Decomposition Products: Carbon monoxide, carbon dioxide, under fire conditions
Incompatibilities: Avoid strong excessive heat, acid, oxidizing agents
Acute Toxicity (oral): LD50 (rat): 20,000 mg/kg
Acute Toxicity (dermal): LD50 (rabbit): 20,800 mg/kg
Skin Irritation: Slight, non-sensitizing, repeated contact may cause mild irritation
Eye Irritation: Mild transient irritation possible
Chronic Toxicity: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity
Summary of Effects: Not considered hazardous based on available data, excessive ingestion over long term could lead to metabolic acidosis in sensitive groups (children, kidney impairment)
Aquatic Toxicity: LC50 (fish, 96h): 40,000 mg/L (virtually nontoxic to aquatic species)
Persistence and Degradability: Readily biodegradable under aerobic and anaerobic conditions
Bioaccumulation Potential: Low, does not persist in biological tissue
Soil Mobility: High, due to complete water solubility, potential to leach but low environmental impact
Other Adverse Effects: Not associated with significant ozone depletion, global warming, or photochemical smog formation
Waste Disposal Methods: Dispose in compliance with local, regional, and national regulations, preferred by incineration or biological treatment
Container Disposal: Rinse thoroughly before recycling or disposal, follow hazardous waste protocol if contaminated
Precautions: Prevent entry into sewers, drains, or waterways, small volumes can be diluted and washed away if approved by regulating authority
Recycling Options: Check for local authorized hazardous-waste or chemical recycling services for surplus material
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not environmentally hazardous per transport regulations
Special Precautions: Secure containers during transport, avoid leaks, keep away from incompatible materials
Limitations: No restrictions for ground, air, or sea transport under normal regulations
OSHA Status: Not a hazardous chemical per OSHA Hazard Communication Standard
TSCA Inventory: Listed
FDA Status: Approved for use in food, cosmetics, and pharmaceuticals
EINECS/ELINCS Number: 200-338-0
REACH Status: Compliant with European Union REACH regulations
SARA Title III: Not regulated as a toxic or hazardous substance
WHMIS Classification: Not controlled under Canadian regulations
Labeling Requirement: None beyond good practice for chemical management
